Disordered protein LAT encodes relative levels of signaling pathways in T cell activation
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 62 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 62 samples: 47 distinct titles, 15 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Disordered protein LAT encodes relative levels of signaling pathways in T cell activationScience (New York, N.Y.) · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE311573_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1369860 and SRA study SRP649121. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 62 sample titles: 47 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9327049 Ctl_8hr_Rep1
- GSM9327050 Ctl_8hr_Rep2
- GSM9327051 Ctl_24hr_Rep1
- GSM9327052 Ctl_24hr_Rep2
- GSM9327053 Stim1_30min_Rep1
- GSM9327054 Stim1_30min_Rep2
- GSM9327055 Stim2_1hr_Rep1
- GSM9327056 Stim2_1hr_Rep2
- GSM9327057 Stim3_90min_Rep1
- GSM9327058 Stim3_90min_Rep2
- GSM9327059 Stim4_2hr_Rep1
- GSM9327060 Stim4_2hr_Rep2
- GSM9327061 Stim5_3hr_Rep1
- GSM9327062 Stim5_3hr_Rep2
- GSM9327063 Stim6_4hr_Rep1
- GSM9327064 Stim6_4hr_Rep2
- GSM9327065 Stim7_8hr_Rep1
- GSM9327066 Stim7_8hr_Rep2
- GSM9327067 Stim8_16hr_Rep1
- GSM9327068 Stim8_16hr_Rep2
- GSM9327069 Stim9_24hr_Rep1
- GSM9327070 Stim9_24hr_Rep2
- GSM9327094 Jurkat T cell, 132 ORF screen, 30 min stimulation, channel 1, ATAC library
- GSM9327095 Jurkat T cell, 132 ORF screen, 30 min stimulation, channel 2, ATAC library
- GSM9327096 Jurkat T cell, 132 ORF screen, 90 min stimulation, channel 1, ATAC library
- GSM9327097 Jurkat T cell, 132 ORF screen, 90 min stimulation, channel 2, ATAC library
- GSM9327098 Jurkat T cell, 132 ORF screen, 30 min stimulation, channel 1, ORF library
- GSM9327099 Jurkat T cell, 132 ORF screen, 30 min stimulation, channel 2, ORF library
- GSM9327100 Jurkat T cell, 132 ORF screen, 90 min stimulation, channel 1, ORF library
- GSM9327101 Jurkat T cell, 132 ORF screen, 90 min stimulation, channel 2, ORF library
- GSM9327102 Primary human CD4 T cell, 7 ORF screen, 90 min stimulation, replicate 1, ATAC library
- GSM9327103 Primary human CD4 T cell, 7 ORF screen, 90 min stimulation, replicate 2, ATAC library
- GSM9327104 Primary human CD4 T cell, 7 ORF screen, 90 min stimulation, replicate 1, ORF library
- GSM9327105 Primary human CD4 T cell, 7 ORF screen, 90 min stimulation, replicate 2, ORF library
- GSM9327106 Primary human CD4 T cell, 25 ORF screen, 90 min stimulation, replicate 1, ATAC library
- GSM9327107 Primary human CD4 T cell, 25 ORF screen, 90 min stimulation, replicate 2, ATAC library
- GSM9327108 Primary human CD4 T cell, 25 ORF screen, 90 min stimulation, replicate 3, ATAC library
- GSM9327109 Primary human CD4 T cell, 25 ORF screen, 90 min stimulation, replicate 1, ORF library
- GSM9327110 Primary human CD4 T cell, 25 ORF screen, 90 min stimulation, replicate 2, ORF library
- GSM9327111 Primary human CD4 T cell, 25 ORF screen, 90 min stimulation, replicate 3, ORF library
+ 22 more — browse all 62 samples with per-sample file links →
- GSE309979 GeoMx GeoMx-DSP Toxic Lipid-induced Epigenetic Activation of ICAM1 in Liver Sinusoidal Endothelium Regulates Myeloid-Driven Fibro-inflammatory Response in MASH 217 samples shares lat, activation
- GSE339049 Severe long-COVID is driven by monocyte reprogramming and broad immune dysregulation linked to herpesvirus activation 48 samples shares lat, activation
- GSE244403 cGAS-STING axis activation drove inflammatory phenotype acquisition of senescent nucleus pulposus cells via p65-mediated transcriptional modulation 12 samples shares lat, activation
- GSE341139 A conserved HAND2-BMP5-SMAD1/5/9 axis drives hepatic stellate cell activation and extracellular matrix overproduction in multiple fibrotic etiologies 10 samples shares lat, activation
- GSE342301 SIRT2 deacylase modulators control B cell metabolic reprogramming in EBV infection and mitogenic activation 8 samples shares lat, activation
- GSE341616 A conserved HAND2-HAND2_OE-SMAD1/5/9 axis drives hepatic stellate cell activation and extracellular matrix overproduction in multiple fibrotic etiologies 5 samples shares lat, activation
- GSE305263 Integrated RNA, translation, and proteome profiling reveals midbody remnants as selectively organized signaling vesicles 42 samples shares lat
- GSE342540 Store-operated calcium signaling modulators improve a dendritic cell-based vaccine against melanoma 9 samples shares lat
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.