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E96A baseline transcriptional changes

GSE311737 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2026/02/04 Platform GPL24676
Summary
APE1/Ref-1 is the primary apurinic/apyrimidinic endonuclease in the base excision repair pathway. To define baseline transcriptional changes resulting from loss of APE1 endonuclease activity, RNA-seq was performed on Pa03C pancreatic ductal adenocarcinoma cell lines engineered to carry a homozygous E96A mutation and on matched Cas9 controls. Cells were cultured under untreated conditions. This dataset provides gene expression profiles associated with impaired APE1 endonuclease function in PDAC cells.
Published in
Targeting APE1 endonuclease activity impairs metastasis and enhances genotoxic therapy response in pancreatic cancer
Kpenu EK, Mijiti M, Gampala S et al. · Research square 2025 · PMID 41510226 · doi:10.21203/rs.3.rs-8197122/v1
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Also filed as BioProject PRJNA1370849 and SRA study SRP649665. Searching any of these in the dataset finder brings you back here.

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