Immune and Repair Mechanisms Underlying Congenital Chagas

In this study, we conducted integrative high-throughput analyses of peripheral blood and placental tissue from naturally infected patients in Bolivia, the country with the highest prevalence of Chagas disease and, consequently, the population with the greatest potential for congenital transmission worldwide. We compared T. cruzi-infected and uninfected patients to characterize parasite-associated alterations. Infected mothers were further classified as transmitters or non-transmitters based on the infant’s infection status, determined by serological and molecular tests. Transmitter and non-transmitter mothers were compared to understand the molecular mechanism associated with congenital transmission risk.