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Role of m⁶A-Modified GAS6 in Rheumatoid Arthritis: Insights from Multi-Omics Analysis

GSE311923 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/01 Platform GPL24676
Summary
Synovial tissue samples were collected from RA and HC were used for m⁶A seq and RNA seq analysis. Peripheral blood mononuclear cells (PBMCs) were isolated from RA and HC. The mRNA expression of GAS6 and MERTK was quantified by qRT-PCR, and inflammatory cytokine (IL-1β, IL-6, IL-10, and TGF-β1) were detected by ELISA. GAS6, MERTK were knocked down in RA-FLS using siRNA interference. CCK-8 were used to assess cell viability, Flow cytometry to assess apoptosis , and Cell scratch assay to evaluate cell migration rate. Immunofluorescence and Western blott was used to determine protein localization and expression.
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Also filed as BioProject PRJNA1371965 and SRA study SRP650203. Searching any of these in the dataset finder brings you back here.

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