GEO series
Ascertaining the effect of switching deregulated Myc ON in KRasG12D-driven mouse lung tumours
GSE312048
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2026/03/31
GPL24247
Summary
The mechanisms by which Myc transcriptionally induces tumour progression is unclear. In an autochthonous mouse model of lung adenocarcinoma driven by oncogenic Kras and deregulated Myc cooperation, we initiated acute activation of Myc exclusively in the tumour epithelial cells to identify the sequence of events and crosstalk in a tumour and its attendent microenvironement in the first week of tumour progression, with a focus on the first 24 hours.
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