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Ascertaining the effect of switching deregulated Myc ON in KRasG12D-driven mouse lung tumours

GSE312048 Mus musculus (mouse) RNA-seq (gene expression) 16 samples Submitted 2026/03/31 Platform GPL24247
At a glance

RNA-seq (gene expression) · mouse · 16 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
16 samples: 6 × KRasG12D_only vs 4 × MycON_7d vs 3 × MycON_8hrs vs 3 × MycON_24hrsGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Summary (written by the submitters)
The mechanisms by which Myc transcriptionally induces tumour progression is unclear. In an autochthonous mouse model of lung adenocarcinoma driven by oncogenic Kras and deregulated Myc cooperation, we initiated acute activation of Myc exclusively in the tumour epithelial cells to identify the sequence of events and crosstalk in a tumour and its attendent microenvironement in the first week of tumour progression, with a focus on the first 24 hours.
This dataset
Open GSE312048 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE312048_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1372107 and SRA study SRP650361. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗
Study design
6 × KRasG12D_only vs 4 × MycON_7d vs 3 × MycON_8hrs vs 3 × MycON_24hrs

Supports a between-group comparison across 16 samples.

How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.