GEO series
MAPK- driven glioma progression and reprogramming of the tumor-associated immune response
GSE312124
Homo sapiens
Expression profiling by high throughput sequencing
10 samples
2026/07/16
GPL24676
Summary
Glioma evolution is associated with disease progression and therapeutic resistance. We recently identified a group of MAPK-driven glioma with CDKN2A homozygous deletion that are low-grade and immune enriched. However, Over time, these tumors can progress to aggressive, higher-grade tumors. While low-grade tumors may be amenable to immunotherapeutic strategies, it is unknown how the tumor and its microenvironment evolve.
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Paper (PMID 42377256) ↗
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