MEK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis
Non-coding RNA profiling · human · 66 samples
- What it is
- Non-coding RNA profilingLevels of RNAs that do not code for proteins, such as miRNA or lncRNA.
- Organism
- Homo sapiens (human)
- Topic
- Colorectal cancerThis series is part of our curated briefing on it.
- Samples
- 66 samples: 22 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Ras-MAPK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesisCell communication and signaling : CCS · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE312197_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
Also filed as BioProject PRJNA1372645 and SRA study SRP650668. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 66 samples.
How we read this: 22 replicated groups read from 66 sample titles; they account for 66 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9340188 HCT116, DMSO, 8h, rep1 HCT116, DMSO, 8h,
- GSM9340189 HCT116, Tram, 8h, rep1 HCT116, Tram, 8h,
- GSM9340190 HCT116, Chir, 8h, rep1 HCT116, Chir, 8h,
- GSM9340191 HCT116, DMSO, 24h, rep1 HCT116, DMSO, 24h,
- GSM9340192 HCT116, Tram, 24h, rep1 HCT116, Tram, 24h,
- GSM9340193 HCT116, Chir, 24h, rep1 HCT116, Chir, 24h,
- GSM9340194 HCT116, DMSO, 72h, rep1 HCT116, DMSO, 72h,
- GSM9340195 HCT116, Tram, 72h, rep1 HCT116, Tram, 72h,
- GSM9340196 HCT116, Chir, 72h, rep1 HCT116, Chir, 72h,
- GSM9340197 HCT116, DMSO, 8h, rep2 HCT116, DMSO, 8h,
- GSM9340198 HCT116, Tram, 8h, rep2 HCT116, Tram, 8h,
- GSM9340199 HCT116, Chir, 8h, rep2 HCT116, Chir, 8h,
- GSM9340200 HCT116, DMSO, 24h, rep2 HCT116, DMSO, 24h,
- GSM9340201 HCT116, Tram, 24h, rep2 HCT116, Tram, 24h,
- GSM9340202 HCT116, Chir, 24h, rep2 HCT116, Chir, 24h,
- GSM9340203 HCT116, DMSO, 72h, rep2 HCT116, DMSO, 72h,
- GSM9340204 HCT116, Tram, 72h, rep2 HCT116, Tram, 72h,
- GSM9340205 HCT116, Chir, 72h, rep2 HCT116, Chir, 72h,
- GSM9340206 HCT116, DMSO, 8h, rep3 HCT116, DMSO, 8h,
- GSM9340207 HCT116, Tram, 8h, rep3 HCT116, Tram, 8h,
- GSM9340208 HCT116, Chir, 8h, rep3 HCT116, Chir, 8h,
- GSM9340209 HCT116, DMSO, 24h, rep3 HCT116, DMSO, 24h,
- GSM9340210 HCT116, Tram, 24h, rep3 HCT116, Tram, 24h,
- GSM9340211 HCT116, Chir, 24h, rep3 HCT116, Chir, 24h,
- GSM9340212 HCT116, DMSO, 72h, rep3 HCT116, DMSO, 72h,
- GSM9340213 HCT116, Tram, 72h, rep3 HCT116, Tram, 72h,
- GSM9340214 HCT116, Chir, 72h, rep3 HCT116, Chir, 72h,
- GSM9340215 SW480, Chir, 24h, rep1 SW480, Chir, 24h,
- GSM9340216 SW480, Chir, 72h, rep1 SW480, Chir, 72h,
- GSM9340217 SW480, Chir, 8h, rep1 SW480, Chir, 8h,
- GSM9340218 SW480, Chir, 24h, rep2 SW480, Chir, 24h,
- GSM9340219 SW480, Chir, 72h, rep2 SW480, Chir, 72h,
- GSM9340220 SW480, Chir, 8h, rep2 SW480, Chir, 8h,
- GSM9340221 SW480, Chir, 24h, rep3 SW480, Chir, 24h,
- GSM9340222 SW480, Chir, 72h, rep3 SW480, Chir, 72h,
- GSM9340223 SW480, Chir, 8h, rep3 SW480, Chir, 8h,
- GSM9340224 SW480, DMSO, 24h, rep1 SW480, DMSO, 24h,
- GSM9340225 SW480, DMSO, 72h, rep1 SW480, DMSO, 72h,
- GSM9340226 SW480, DMSO, 8h, rep1 SW480, DMSO, 8h,
- GSM9340227 SW480, DMSO, 24h, rep2 SW480, DMSO, 24h,
+ 26 more — browse all 66 samples with per-sample file links →
- GSE12032 Inherent gene signature of stage II and III colorectal cancer leads in individual recurrence 198 samples same disease briefing · shares colorectal
- GSE250000 Bulk RNA-sequencing of transduced colorectal cancer cell line HCT-116 and breast cancer cell line MCF-7 overexpressing full-lenght p53β or p53β-stop-lost. 4 samples same disease briefing · shares colorectal
- GSE109308 Single-cell transcriptomic survey of adenomatous polyposis patients with germline APC mutations 97 samples same disease briefing
- GSE110009 Single cell transcriptome landscape of primary and metastatic tumor in colon cancer 76 samples same disease briefing
- GSE275078 In vitro drug screening of RAF/MEK/ERK Inhibitors in combination with Autophagy inhibition in the context of two PDA Cell Lines 136 samples shares mek, inhibition
- GSE281506 Combining Menin and MEK inhibition to target poor prognosis KMT2A-rearranged RAS pathway-mutant acute myeloid leukemia 42 samples shares mek, inhibition
- GSE306221 Transient inhibition of MEK/ERK and WNT pathways enhances direct differentiation of primed hPSCs into functional trophoblast stem cells 18 samples shares mek, inhibition
- GSE254732 Inhibition of PCSK9 with evolocumab modulates lipoproteins and monocyte activation in high-risk ASCVD subjects 215 samples shares inhibition, protein
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.