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Single-nucleus RNA sequencing of the cells obtained from acupoint BL23 (Shenshu) in low back pain.

GSE312510 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/12/31 Platform GPL24676
Summary
The cellular and molecular dynamics at human acupuncture points remain largely unexplored. To address this, we developed a novel acupuncture-needle technique capable of collecting sufficient numbers of cells from acupuncture points during treatment. Using this approach in combination with single-nucleus RNA sequencing (snRNA-seq), we identified heterogeneous cell populations at the acupoint BL23. This study enabled characterization of the cellular and transcriptional changes occurring before and after acupuncture treatment in patients with lower back pain (lumbar sprain), offering new insights into the mechanisms underlying acupuncture-induced pain relief.
Published in
Single cell transcriptomic analysis reveals dynamic cellular composition changes at acupuncture point BL23 (Shenshu) in low back pain
Zhao G, Wu X, Huang S et al. · Molecular pain 2025 · PMID 41312958 · doi:10.1177/17448069251405974
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Also filed as BioProject PRJNA1374078 and SRA study SRP651374. Searching any of these in the dataset finder brings you back here.

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