GEO series
Effect of HNF1A-MODY on stem cell islets
GSE312607
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/06/10
GPL34284
Summary
This project investigates the impact of the hotspot mutation P291fsinsC in HNF1A-MODY (Maturity-Onset Diabetes of the Young) on stem cell-derived islets. RNA sequencing (RNA-seq) was performed on islets differentiated from mutant and control HNF1A-MODY stem cells to study the mutation's effect on gene expression. By comparing the transcriptomic profiles of these islets, the study aims to uncover molecular mechanisms underlying the dysfunction caused by the P291fsinsC mutation during islet development and maturation.
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Paper (PMID 41887801) ↗
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