An ASCL1 C-Terminal Phospho-Degron Control ASCL1 Protein Stability in Small Cell Lung Cancer
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 9 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Small cell lung cancerThis series is part of our curated briefing on it.
- Samples
- 9 samples: 2 × Flag ChIP-seq on CORL47 cells expressing DOX-ON ASCL1WT-Flag vs 2 × ASCL1 ChIP-seq on CORL47 cells expressing empty vector vs 2 × Flag ChIP-seq on CORL47 cells expressing DOX-ON ASCL1del217-236-FlagGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE312626_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1375549 and SRA study SRP651692. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 6 samples.
How we read this: 3 replicated groups read from 9 sample titles; they account for 6 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9350469 Flag ChIP-seq on CORL47 cells expressing DOX-ON ASCL1WT-Flag Rep1 Flag ChIP-seq on CORL47…
- GSM9350470 Flag ChIP-seq on CORL47 cells expressing DOX-ON ASCL1WT-Flag Rep2 Flag ChIP-seq on CORL47…
- GSM9350471 ASCL1 ChIP-seq on CORL47 cells expressing empty vector Rep1 ASCL1 ChIP-seq on CORL4…
- GSM9350472 ASCL1 ChIP-seq on CORL47 cells expressing empty vector Rep2 ASCL1 ChIP-seq on CORL4…
- GSM9350473 Flag ChIP-seq on CORL47 cells expressing DOX-ON ASCL1del217-236-Flag Rep1 Flag ChIP-seq on CORL47…
- GSM9350474 Flag ChIP-seq on CORL47 cells expressing DOX-ON ASCL1del217-236-Flag Rep2 Flag ChIP-seq on CORL47…
- GSM9350475 Input of CORL47 cells expressing DOX-ON ASCL1WT-Flag
- GSM9350476 Input of CORL47 cells expressing empty vector
- GSM9350477 Input of CORL47 cells expressing DOX-ON ASCL1del217-236
- GSE230649 MYC family amplification dictates sensitivity to BET bromodomain protein inhibitor Mivebresib (ABBV-075) in small cell lung cancer 28 samples same disease briefing · shares protein, small, lung
- GSE256347 SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing [RNA-seq] 13 samples same disease briefing · shares control, small, lung
- GSE255757 Formation of malignant, metastatic small cell lung cancers through overproduction of cMYC protein in TP53 and RB1 depleted pulmonary neuroendocrine cells derived from human embryonic stem cells 6 samples same disease briefing · shares protein, small, lung
- GSE322515 Regulation of neuronal invasion of small cell lung cancer by STMN2/β-alanine-controlled metabolic reprogramming [beta-alanine-RNAseq] 6 samples same disease briefing · shares control, small, lung
- GSE322516 Regulation of neuronal invasion of small cell lung cancer by STMN2/β-alanine-controlled metabolic reprogramming [Proximal_and_Distal-RNA-seq] 6 samples same disease briefing · shares control, small, lung
- GSE337245 Transcriptome profiling of SCRMP knockout and control NCI-H69 small cell lung cancer cells 6 samples same disease briefing · shares control, small, lung
- GSE255825 Formation of malignant, metastatic small cell lung cancers through overproduction of cMYC protein in TP53 and RB1 depleted pulmonary neuroendocrine cells derived from human embryonic stem cells [bulk RNA-seq] 5 samples same disease briefing · shares protein, small, lung
- GSE297358 Loss of NOTCH2 Creates a TRIM28-Dependent Vulnerability in Small Cell Lung Cancer [ChIP-seq] 29 samples same disease briefing · shares small, lung
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.