GEO series
Lesion-remote astrocytes govern microglia-mediated white matter repair II
GSE312871
Mus musculus
Expression profiling by high throughput sequencing
198 samples
2026/01/08
GPL24247
Summary
RNA sequencing was applied to examine changes in gene expression in astrocytes in spared tissue regions both rostral and caudal to the injury site in a mouse model of incomplete spinal cord injury (ISCI) over multiple post-injury time points. The RiboTag method was used to isolate astrocyte ribosome-associated mRNAs from the spinal cord of wild type mice and mice with astrocyte-specific conditional gene deletion (cKO) of a known transcriptional regulators of reactivity, STAT3 (Stat3 knockout: Stat3-cKO).
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Paper (PMID 41407858) ↗
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