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Advanced dual-payload antibody-drug conjugates (DualADCs) for targeted cancer chemo-immunotherapy

GSE312957 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/03/02 Platform GPL21273
Summary
Antibody–drug conjugates (ADCs) are a powerful class of targeted cancer therapeutics that combine the specificity of monoclonal antibodies with the potency of cytotoxic payloads. In this study, we developed novel dual-payload ADC (DualADC) platforms that enable co-delivery of a chemotherapeutic agent for direct tumor cell killing and a toll-like receptor agonist to stimulate antitumor immunity. Using triple-negative breast cancer (TNBC) as a model, we established advanced cysteine/lysine co-conjugation strategies optimized for antibody–drug ratio (ADR) and drug–drug ratio (DDR). These refinements minimized hydrophobicity-induced precipitation, enhanced conjugation efficiency, and improved formulation stability. In vivo evaluations in two xenograft mouse models demonstrated strong antitumor efficacy, highlighting the therapeutic potential of DualADCs as a next-generation approach for synergistic chemo-immunotherapy.
Published in
Advanced CD276-Targeting Dual-Payload Antibody-Drug Conjugates for Cancer Therapy
Zhou Z, Ballard D, Zhang J et al. · Cancer research communications 2026 · PMID 42013359 · doi:10.1158/2767-9764.CRC-26-0059
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Also filed as BioProject PRJNA1377655 and SRA study SRP653483. Searching any of these in the dataset finder brings you back here.

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