microRNA-25 drives initial resistance to immune checkpoint therapy by repressing innate and humoral immunity via Syndecan3
Non-coding RNA profiling · mouse · 51 samples
- What it is
- Non-coding RNA profilingLevels of RNAs that do not code for proteins, such as miRNA or lncRNA.
- Organism
- Mus musculus (mouse)
- Samples
- 51 samples: 16 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- microRNA-25 drives immune checkpoint therapy resistance by repressing innate and humoral immunity via Syndecan-3Nature communications · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE313080_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
Also filed as BioProject PRJNA1378223 and SRA study SRP653700. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 31 samples read as cases, 3 as controls.
How we read this: 16 replicated groups read from 51 sample titles; they account for 51 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9358820 Tumor_Comb_rep1 Tumor_Comb
- GSM9358821 Tumor_Comb_rep2 Tumor_Comb
- GSM9358822 Tumor_Comb_rep3 Tumor_Comb
- GSM9358823 Tumor_GVAX_rep1 Tumor_GVAX
- GSM9358824 Tumor_GVAX_rep2 Tumor_GVAX
- GSM9358825 Tumor_GVAX_rep3 Tumor_GVAX
- GSM9358826 Tumor_Control_rep1 Tumor_Control
- GSM9358827 Tumor_Control_rep2 Tumor_Control
- GSM9358828 Tumor_Control_rep3 Tumor_Control
- GSM9358829 Tumor_25KO_rep1 Tumor_25KO
- GSM9358830 Tumor_25KO_rep2 Tumor_25KO
- GSM9358831 Tumor_25KO_rep3 Tumor_25KO
- GSM9358832 Tumor_25KO_rep4 Tumor_25KO
- GSM9358833 Tumor_25KO_rep5 Tumor_25KO
- GSM9358834 Tumor_NTC_rep1 Tumor_NTC
- GSM9358835 Tumor_NTC_rep2 Tumor_NTC
- GSM9358836 Tumor_NTC_rep3 Tumor_NTC
- GSM9358837 Tumor_NTC_rep4 Tumor_NTC
- GSM9358838 Tumor_NTC_rep5 Tumor_NTC
- GSM9358839 NTC_noIFN_rep1 NTC_noIFN
- GSM9358840 NTC_noIFN_rep2 NTC_noIFN
- GSM9358841 NTC_IFN_rep1 NTC_IFN
- GSM9358842 NTC_IFN_rep2 NTC_IFN
- GSM9358843 NTC_IFN_rep3 NTC_IFN
- GSM9358844 KO_noIFN_rep1 KO_noIFN
- GSM9358845 KO_noIFN_rep2 KO_noIFN
- GSM9358846 KO_noIFN_rep3 KO_noIFN
- GSM9358847 KO_IFN_rep1 KO_IFN
- GSM9358848 KO_IFN_rep2 KO_IFN
- GSM9358849 MC38 tumor, miR-25 KO, rep1 MC38 tumor, miR-25 KO,
- GSM9358850 MC38 tumor, miR-25 KO, rep2 MC38 tumor, miR-25 KO,
- GSM9358851 MC38 tumor, miR-25 KO, rep3 MC38 tumor, miR-25 KO,
- GSM9358852 MC38 tumor, Control, rep1 MC38 tumor, Control,
- GSM9358853 MC38 tumor, Control, rep2 MC38 tumor, Control,
- GSM9358854 MC38 tumor, Control, rep3 MC38 tumor, Control,
- GSM9358855 MC38 tumor, Control, rep4 MC38 tumor, Control,
- GSM9358856 miR25 sgRNA1, pooled knockout, rep1 miR25 sgRNA1, pooled kn…
- GSM9358857 miR25 sgRNA1, pooled knockout, rep2 miR25 sgRNA1, pooled kn…
- GSM9358858 miR25 sgRNA1, pooled knockout, rep3 miR25 sgRNA1, pooled kn…
- GSM9358859 miR25 single clone knockout 14, rep1 miR25 single clone knoc…
+ 11 more — browse all 51 samples with per-sample file links →
- GSE254919 Extracellular vesicles from obese visceral adipose promote pancreatic cancer development and resistance to immune checkpoint blockade therapy [ATAC-seq] 12 samples shares resistance, checkpoint, therapy
- GSE307388 Immune checkpoint blockade augments lymphodepleting chemotherapy-induced antitumor immunity by expanding effector CD8+ T cell clones in preclinical models of cancer 12 samples shares checkpoint, immunity, therapy
- GSE293819 Monitoring systemic immune responses to checkpoint inhibition in breast cancer reveals host responses and mechanisms of resistance 142 samples shares resistance, checkpoint
- GSE278990 Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity 73 samples shares checkpoint, immunity
- GSE268774 Lymph node macrophages drive immune tolerance and resistance to cancer therapy by expression of the immune-regulatory cytokine IL-33 [RNA-seq] 48 samples shares resistance, therapy
- GSE278980 Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity - RNA-seq of C57BL/6 murine models 32 samples shares checkpoint, immunity
- GSE310501 Mesothelioma location influences the tumour microenvironment and immune checkpoint therapy response in preclinical models 31 samples shares checkpoint, therapy
- GSE281467 Coactivation of innate immune suppressive cells induces acquired resistance against cancer immunotherapy targeting the innate immune system [TIICs RNA-seq] 30 samples shares resistance, therapy
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.