GEO series
RASA3 inhibits Th1 differentiation and attenuates inflammatory immune response by restricting the HCK kinase
GSE313543
Mus musculus
Expression profiling by high throughput sequencing
24 samples
2026/07/05
GPL24247
Summary
Type I immunity is marked by IFN-γ, with Th1 cells as a key subset; however, intrinsic negative regulators of Th1 remain poorly defined. We identified RASA3 as such a regulator, whose expression declines during Th1 differentiation. T cell-specific RASA3 knockout enhances Th1 differentiation and exacerbates allergic contact dermatitis. Mechanistically, RASA3 inhibits Hck mRNA translation via RPL36A. HCK then phosphorylates STAT4 at Y693, driving STAT4 dimerization, nuclear entry, and IFN-γ expression. This RASA3–HCK–STAT4 axis reveals a novel mechanism for Th1 negative regulation and offers potential therapeutic targets.
Download
NCBI GEO page ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
mouse RNA-seq datasets →
Similar datasets
- GSE292862 Modelling mouse embryogenesis from chemically induced totipotent stem cells 22 samples
- GSE185862 A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation 95 samples
- GSE304862 Semaglutide and exercise synergy in obesity: preserving muscle mass and uncovering organ crosstalk 209 samples
- GSE293315 MRPGRX2 Antagonist Treatment Prevents Inflammation and Disease in a Mouse Model of Atopic Dermatitis Dataset 2 35 samples
- GSE255837 Dysregulation of the Normal Wound Healing Cascade in Volumetric Muscle Loss Injury 30 samples
- GSE341948 Multi-tissue transcriptomic landscape reveals synergistic mechanisms of exercise and GLP-1 agonist in ameliorating diabetic phenotypes in db/db mice 12 samples
- GSE337190 CAR-NKT cells induce low cytokine release syndrome by targeting hyperinflammatory macrophages with mitigation from GM-SCF inhibition. 24 samples
- GSE306116 Caspase-3 Control of RNA Splicing and Mitochondrial Dynamics in Microglia during Parkinson’s Disease [RNA-Seq] 12 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.