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YBX1 Drives Post-Myocardial Infarction Angiogenesis via an m⁶A-IGF2BP1/3 Dependent Stabilization of HIF-1α mRNA

GSE313688 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2026/01/18 Platform GPL24676
Summary
Angiogenesis plays a vital role in myocardial repair following myocardial infarction (MI). Y-box binding protein 1 (YBX1), an RNA-binding protein known for its role in cancer, is found to be significantly upregulated in endothelial cells within the peri-infarct zone and in hypoxic human umbilical vein endothelial cells (HUVECs). Using in vitro and in vivo models, we demonstrate that YBX1 enhances endothelial cell viability, proliferation, migration, and tube formation. Endothelial-specific overexpression of YBX1 in a murine MI model improved cardiac function and angiogenesis, while YBX1 knockdown aggravated cardiac injury. Transcriptome (RNA-seq) analysis revealed that YBX1 deficiency disrupts HIF-1α signaling. Mechanistically, YBX1 forms a complex with IGF2BP1/3 to stabilize HIF-1α mRNA through N⁶-methyladenosine (m⁶A) modification, thereby promoting angiogenesis and cardiac repair.
Published in
YBX1 promotes angiogenesis after myocardial infarction by stabilizing HIF1α mRNA via m(6)A signaling
Bi F, Yu T, Liu H et al. · iScience 2026 · PMID 41732278 · doi:10.1016/j.isci.2026.114810
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Also filed as BioProject PRJNA1348458 and SRA study SRP637005. Searching any of these in the dataset finder brings you back here.

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