GEO series
Loss of NADPH-producing enzymes accelerates pancreatic precancerous lesions
GSE313699
Mus musculus
Expression profiling by high throughput sequencing
14 samples
2025/12/15
GPL34290
Summary
Acinar-to-ductal metaplasia (ADM) is a reversible cell state that facilitates pancreas repair following injury. Oncogenic KRAS mutations can progress ADM to pancreatic intraepithelial neoplasia (PanIN) and pancreatic ductal adenocarcinoma. Metabolism is extensively reprogrammed in cancer, but the metabolic alterations in precancerous lesions are understudied. Using RNA-sequencing and targeted metabolomics from isolated acinar cells we identified global changes in central carbon metabolism genes and metabolites during ADM formation.
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