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Codonopsis pilosula polysaccharides mitigates Brucella abortus outer membrane protein 19-induced uterine damage via macrophage adhesion and calcium signaling

GSE314097 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2026/01/19 Platform GPL24247
Summary
Brucellosis is a zoonotic disease caused by the Brucella species. Its pathogenesis is closely linked to bacterial evasion of macrophage-mediated killing, induction of a pro-inflammatory cytokine storm, and immune-mediated pathological damage. Accumulating evidence indicates that Codonopsis pilosula polysaccharides (CPPS) inhibits inflammatory signaling, enhances macrophage phagocytosis, and exerts immunomodulatory effects across multiple organs. However, the therapeutic potential of CPPS against brucellosis remains largely unexplored.
Published in
Codonopsis pilosula polysaccharide attenuates the inflammatory response in macrophages induced by Brucella abortus outer membrane protein 19 via regulating ATP2A1 to modulate cell adhesion and calcium signaling
Wang X, Zhou Z, Zhang N et al. · Frontiers in immunology 2026 · PMID 42311667 · doi:10.3389/fimmu.2026.1831002
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Also filed as BioProject PRJNA1390095 and SRA study SRP655969. Searching any of these in the dataset finder brings you back here.

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