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Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma [HuCCT-1]

GSE314257 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/06/25 Platform GPL30173
Summary
Epigenetic alterations play an increasingly recognized role in carcinogenesis and in the development of resistance to anticancer therapies. In this study, we examined the expression of epigenetic genes to investigate their interplay in cholangiocarcinoma (CCA). We examined 257 epigenetic genes (EpiGs) in transcriptomic data from HuCCT-1 iCCA cells under hypoxia (1% O₂) for 24 h. We observed that exposing the HuCCT-1 iCCA cell line to hypoxia increased the expression of key epigenetic regulators. Our results suggest that hypoxia may contribute to the activation of a shared epigenetic program associated with malignant transformation and poor prognosis.
Published in
Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma
Lopez-Pascual A, Elurbide J, Valbuena-Goiricelaya E et al. · Frontiers in cell and developmental biology 2026 · PMID 42326014 · doi:10.3389/fcell.2026.1765945
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Also filed as BioProject PRJNA1390614 and SRA study SRP656349. Searching any of these in the dataset finder brings you back here.

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