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Cis-regulation of IL-22 gene in type 3 immune cells [ATAC-seq_Mnk3]

GSE314554 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2026/02/02 Platform GPL17021
Summary
IL-22 is a signature cytokine of type 3 immune cells which include ILC3s and Th17/22. Despite its critical role in barrier tissue integrity, the field lacks the understanding of cis mechanisms regulating IL-22. We took initiative to study and reveal the regulatory mechanisms controlling IL-22 expression in ILC3s and Th17/22 cells.
Published in
Cell type-specific enhancers regulate IL-22 expression in innate and adaptive type 3 lymphoid cells
Saini A, Hopkins LS, Serna VA et al. · Nature communications 2026 · PMID 41832176 · doi:10.1038/s41467-026-70636-4
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Also filed as BioProject PRJNA1217908 and SRA study SRP560935. Searching any of these in the dataset finder brings you back here.

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