Lamin A/C maintains genome topology and regulates transcriptional programs essential for virus-driven B cell activation.
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 28 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 28 samples: 13 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Lamin A/C maintains genome topology and regulates transcriptional programs essential for virus-driven B cell activationbioRxiv : the preprint server for biology · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE314558_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1391501 and SRA study SRP656782. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 28 samples.
How we read this: 13 replicated groups read from 28 sample titles; they account for 28 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9401373 LMNAC WT, untreated, replicate 1 LMNAC WT, untreated,
- GSM9401374 LMNAC WT, untreated, replicate 2 LMNAC WT, untreated,
- GSM9401375 LMNAC WT, untreated, replicate 3 LMNAC WT, untreated,
- GSM9401376 LMNAC WT, G9ai treated, replicate 2 LMNAC WT, G9ai treated,
- GSM9401377 LMNAC WT, G9ai treated, replicate 3 LMNAC WT, G9ai treated,
- GSM9401378 LMNAC KO, untreated, replicate 1 LMNAC KO, untreated,
- GSM9401379 LMNAC KO, untreated, replicate 2 LMNAC KO, untreated,
- GSM9401380 LMNAC KO, untreated, replicate 3 LMNAC KO, untreated,
- GSM9401421 LMNAC WT input for CTCF, replicate 1 LMNAC WT input for CTCF,
- GSM9401422 LMNAC WT input for CTCF, replicate 2 LMNAC WT input for CTCF,
- GSM9401423 LMNAC KO input for CTCF, replicate 1 LMNAC KO input for CTCF,
- GSM9401424 LMNAC KO input for CTCF, replicate 2 LMNAC KO input for CTCF,
- GSM9401425 CTCF CHIP for LMNAC WT, replicate 1 CTCF CHIP for LMNAC WT,
- GSM9401426 CTCF CHIP for LMNAC WT, replicate 2 CTCF CHIP for LMNAC WT,
- GSM9401427 CTCF CHIP for LMNAC KO, replicate 1 CTCF CHIP for LMNAC KO,
- GSM9401428 CTCF CHIP for LMNAC KO, replicate 2 CTCF CHIP for LMNAC KO,
- GSM9401429 LMNAC WT input for H3K9me2, replicate 1 LMNAC WT input for H3K9…
- GSM9401430 LMNAC WT input for H3K9me2, replicate 2 LMNAC WT input for H3K9…
- GSM9401431 LMNAC KO input for H3K9me2, replicate 1 LMNAC KO input for H3K9…
- GSM9401432 LMNAC KO input for H3K9me2, replicate 2 LMNAC KO input for H3K9…
- GSM9401433 H3K9me2 CHIP for LMNAC WT, replicate 1 H3K9me2 CHIP for LMNAC …
- GSM9401434 H3K9me2 CHIP for LMNAC WT, replicate 2 H3K9me2 CHIP for LMNAC …
- GSM9401435 H3K9me2 CHIP for LMNAC KO, replicate 1 H3K9me2 CHIP for LMNAC …
- GSM9401436 H3K9me2 CHIP for LMNAC KO, replicate 2 H3K9me2 CHIP for LMNAC …
- GSM9401860 HiC of LMNAC WT, replicate 1 HiC of LMNAC WT,
- GSM9401861 HiC of LMNAC WT, replicate 2 HiC of LMNAC WT,
- GSM9401862 HiC of LMNAC KO, replicate 1 HiC of LMNAC KO,
- GSM9401863 HiC of LMNAC KO, replicate 2 HiC of LMNAC KO,
- GSE309174 Stem cell activation in organ culture reveals novel transcriptional programs underlying metabolic, fibrotic, vascular, and immune dysregulation in uterine leiomyomas 25 samples shares activation, programs
- GSE335887 Transcriptional regulation of disease-relevant microglial activation programs 8 samples shares activation, programs
- GSE264550 Machine learning identifies activation of RUNX/AP-1 as drivers of mesenchymal and fibrotic regulatory programs in gastric cancer 25 samples shares activation, programs
- GSE248208 Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibition 99 samples shares activation
- GSE245249 CRISPR activation screens identify the SWI-SNF ATPases as suppressors of ferroptosis 65 samples shares activation
- GSE225251 Enhancer infestation drives tumorigenic activation of inactive compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma 26 samples shares activation
- GSE304612 Inhibition of p300/CREBBP catalytic activity drives context-dependent transcriptional activation in AML. [ChIP-seq] 95 samples shares activation
- GSE271090 Centralized control of dynamic gene regulatory circuits governs human T cell rest and activation 443 samples shares activation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.