GEO series
Temporal Transcriptomic Profiling Identifies Core Regulators in Cytokine-Induced Gut Barrier Disruption in Differentiated Caco-2 Cells
GSE314628
Homo sapiens
Expression profiling by high throughput sequencing
73 samples
2026/06/18
GPL24676
Summary
The intestinal epithelial barrier is a primary governor for gut homeostasis, and its disruption is a critical factor in the pathogenesis of many inflammatory diseases including Inflammatory Bowel Diseases (IBD). Although strategies to restore and enhance barrier function have been proposed as promising therapeutic approaches for treating inflammation-associated intestinal disorders, most therapies in development act on immune-cell response dampening rather than directly reinforcing epithelial function.
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Paper (PMID 42257857) ↗
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