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Two translocation mechanisms drive neural stem cell dissemination into the human fetal cortex

GSE314657 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2026/06/21 Platform GPL34281
Summary
The strong size increase of the human neocortex is supported by a neural stem cell population, the basal radial glial (bRG) cells. Using live imaging of human fetal tissue and cortical organoids, we identify two translocation mechanisms for bRG cell colonization of the human neocortex. On top of an actomyosin-dependent movement called mitotic somal translocation (MST), we identify a microtubule dependent motion occurring during interphase, that we call interphasic somal translocation (IST). We show that IST is driven by the dynein motor and its activator LIS1, that are recruited to the nuclear envelope by the LINC complex, while MST is controlled by the mitotic cell rounding pathway. 85% of bRG cell translocation is due to IST, for a total movement of 0,67 mm per month of gestation. Our work identifies how bRG cells colonize the human fetal cortex and further shows that IST and MST also occur in bRG-related glioblastoma cells.
Published in
Two translocation mechanisms drive neural stem cell dissemination into the human fetal cortex
Wimmer R, Brunet Avalos C, Lestienne P et al. · Neuron 2026 · PMID 41844158 · doi:10.1016/j.neuron.2026.02.002
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Also filed as BioProject PRJNA1379275. Searching any of these in the dataset finder brings you back here.

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