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Chromatin accessibility and transcriptome in human neuronal model exposed to Parkinson's environmental toxins [ATAC-Seq]

GSE315113 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/12/30 Platform GPL24676
Summary
Parkinson's disease is a complex neurodegenerative disorder where environmental factors play a predominant role in sporadic cases. While environmental toxins are implicated in PD pathogenesis via epigenetic pathways, the specific alterations in chromatin accessibility induced by these toxins remain poorly characterized. To address this gap, we established in vitro models using the human neuroblastoma cell line SH SY5Y, a well established neuronal model, exposed to the PD associated environmental toxins rotenone and MPP+. We performed RNA sequencing to profile the transcriptome and Assay for Transposase-Accessible Chromatin sequencing to map genome-wide chromatin accessibility landscapes under toxin exposed conditions. This integrated dataset provides a comprehensive resource detailing both gene expression and chromatin accessibility dynamics in response to PD relevant environmental neurotoxins and will facilitate investigations into transcriptional regulation, biomarker discovery, and the epigenetic basis of environmentally linked sporadic PD.
Published in
Chromatin accessibility and transcriptome in human neuronal model exposed to Parkinson's environmental toxins
Hong J, Huang J · Scientific data 2026 · PMID 41639107 · doi:10.1038/s41597-026-06626-4
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Direct links to NCBI, no account and no request form: the whole study as GSE315113_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1395029 and SRA study SRP658577. Searching any of these in the dataset finder brings you back here.

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