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Regulation of transcriptomic profile by ZL0580 and JQ1

GSE315344 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/27 Platform GPL18573
Summary
Epigenetic suppression and durable silencing of HIV represent a promising strategy to achieve ART-free remission, consistent with the “block and lock” HIV cure paradigm. BRD4 is a host epigenetic reader and plays a critical role in HIV transcriptional regulation. We previously identified ZL0580, a first-in-class BRD4-selective small molecule that epigenetically suppresses HIV, whereas the pan-BET/BRD4 inhibitor JQ1 activates HIV transcription. The present study utilizes RNA-Sequencing (RNA-Seq) to examine the impact of ZL0580 and JQ1 on transcriptomic profile in the latently HIV-infected J-Lat cells (Clone 10.6). In summary, ZL0580 induces a transcriptomic profile opposing to that induced by JQ1, which is highly consistent the opposing effects of the two compounds on HIV transcription and latency.
Published in
Mechanistic insights and in vivo HIV suppression by the BRD4-targeting small molecule ZL0580
Kumar N, Ma Z, Long F et al. · PLoS pathogens 2026 · PMID 41628279 · doi:10.1371/journal.ppat.1013449
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Also filed as BioProject PRJNA1395699 and SRA study SRP659065. Searching any of these in the dataset finder brings you back here.

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