GEO series
Recurrent FOXA1 mutation redirects NIPBL chromatin distribution
GSE315393
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
12 samples
2026/05/06
GPL24676
Summary
A recurrent FOXA1 mutation (R219S) in prostate cancer redirects FOXA1-NIPBL to TAD boundaries by recognizing a non-canonical motif, fostering a more insulated and tumor-aggressive genome.
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