Glioblastoma cells imitate neuronal excitability in humans
Single-cell RNA-seq · human · 82 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Topic
- GlioblastomaThis series is part of our curated briefing on it.
- Samples
- 82 samples: 44 × aAP vs 38 × noGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Combined patch-clamp electrophysiology and single-cell genomic analysis reveal spiking tumor cells at the neocortical glioblastoma interface in humansNeuro-oncology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE315516_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1398184. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 82 samples.
How we read this: 2 replicated groups read from 82 sample titles; they account for 82 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9429945 Patient HCL619 cell 149, aAP status: aAP aAP
- GSM9429946 Patient HCL619 cell 150, aAP status: no no
- GSM9429947 Patient HCL629 cell 154, aAP status: aAP aAP
- GSM9429948 Patient HCL629 cell 156, aAP status: no no
- GSM9429949 Patient HCL629 cell 157, aAP status: no no
- GSM9429950 Patient HCL629 cell 158, aAP status: no no
- GSM9429951 Patient HCL629 cell 160, aAP status: aAP aAP
- GSM9429952 Patient HCL629 cell 161, aAP status: no no
- GSM9429953 Patient HCL629 cell 165, aAP status: no no
- GSM9429954 Patient HCL629 cell 167, aAP status: no no
- GSM9429955 Patient HCL629 cell 169, aAP status: aAP aAP
- GSM9429956 Patient HCL629 cell 170, aAP status: no no
- GSM9429957 Patient HCL934 cell 64, aAP status: no no
- GSM9429958 Patient HCL934 cell 66, aAP status: no no
- GSM9429959 Patient HCL738 cell 84, aAP status: no no
- GSM9429960 Patient HCL738 cell 85, aAP status: aAP aAP
- GSM9429961 Patient HCL738 cell 86, aAP status: aAP aAP
- GSM9429962 Patient HCL738 cell 87, aAP status: aAP aAP
- GSM9429963 Patient HCL738 cell 89, aAP status: aAP aAP
- GSM9429964 Patient HCL738 cell 90, aAP status: aAP aAP
- GSM9429965 Patient HCL738 cell 92, aAP status: aAP aAP
- GSM9429966 Patient HCL738 cell 93, aAP status: aAP aAP
- GSM9429967 Patient HCL560 cell 110, aAP status: no no
- GSM9429968 Patient HCL560 cell 111, aAP status: aAP aAP
- GSM9429969 Patient HCL560 cell 112, aAP status: aAP aAP
- GSM9429970 Patient HCL560 cell 113, aAP status: aAP aAP
- GSM9429971 Patient HCL560 cell 116, aAP status: no no
- GSM9429972 Patient HCL560 cell 117, aAP status: aAP aAP
- GSM9429973 Patient HCL560 cell 118, aAP status: aAP aAP
- GSM9429974 Patient HCL560 cell 119, aAP status: no no
- GSM9429975 Patient HCL560 cell 121, aAP status: no no
- GSM9429976 Patient HCL560 cell 122, aAP status: no no
- GSM9429977 Patient HCL560 cell 123, aAP status: no no
- GSM9429978 Patient HCL560 cell 124, aAP status: no no
- GSM9429979 Patient HCL594 cell 141, aAP status: no no
- GSM9429980 Patient HCL594 cell 142, aAP status: no no
- GSM9429981 Patient HCL594 cell 143, aAP status: aAP aAP
- GSM9429982 Patient HCL934 cell 72, aAP status: no no
- GSM9429983 Patient HCL934 cell 76, aAP status: no no
- GSM9429984 Patient HCL934 cell 82, aAP status: no no
+ 42 more — browse all 82 samples with per-sample file links →
- GSE112648 SOXC factors as suppressors modulate Rho activity to promote neuronal reprogramming of human glioblastoma cells 18 samples same disease briefing · shares glioblastoma, neuronal
- GSE112645 SOXC factors as suppressors modulate Rho activity to promote neuronal reprogramming of human glioblastoma cells 12 samples same disease briefing · shares glioblastoma, neuronal
- GSE131928 single cell RNA-seq analysis of adult and paediatric IDH-wildtype Glioblastomas 2 samples same disease briefing · shares glioblastoma
- GSE107560 Ivy Glioblastoma Atlas Project 305 samples same disease briefing · shares glioblastoma
- GSE13041 Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age 267 samples same disease briefing · shares glioblastoma
- GSE112650 SOX4/11 Enhances NGN2 Reprogramming Glioblastoma Cells into Neuron Cells by Modulating RhoA and CDC42/RAC1 Pathway Activity 30 samples same disease briefing · shares glioblastoma
- GSE10878 Integrative Genome-wide Analysis of Glioblastoma. 60 samples same disease briefing · shares glioblastoma
- GSE115459 Exosome-transmitted RVT1 from reactive astrocytes promotes recurrence glioblastoma proliferation 9 samples same disease briefing · shares glioblastoma
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.