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ChIP-Seq analysis of SIRT6 and KDM5C in pancreatic cancer cell line

GSE315635 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 3 samples Submitted 2026/06/03 Platform GPL24676
Summary
Pancreatic cancer is among the deadliest malignant tumours, characterized by rapid progression, poor prognosis, and high mortality.SIRT6 and KDM5C plays an important role in tumorigenesis, development, and drug resistance .However, the precise molecular mechanisms through which SIRT6 and KDM5C inhibit tumorigenesis and metastasis in pancreatic cancer, as well as its role in cancer stem cells (CSCs), remain unclear.Collectively, our findings identify SIRT6 and KDM5C as key regulators of pancreatic cancer progression and suggest that they represent potential targets for early diagnosis and therapeutic intervention.
Published in
SIRT6 cooperates with KDM5C to transcriptionally silence MICAL2 and inhibit tumorigenesis in pancreatic cancer
Leng S, Liu W, Han Y et al. · Cell communication and signaling : CCS 2026 · PMID 41998659 · doi:10.1186/s12964-026-02886-0
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Also filed as BioProject PRJNA1398360 and SRA study SRP659811. Searching any of these in the dataset finder brings you back here.

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