GEO series
MAPK14 Governs Mammalian Müller glia Fate Determination between Gliosis and Reprogramming
GSE316279
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/01/18
GPL29480
Summary
Irreversible loss of retinal neurons is the leading cause of blindness. Harnessing the latent stem cell potential of mammalian Müller glia offers a promising strategy for endogenous retinal regeneration. Shifting the Müller glia response from gliosis to regeneration after retinal injury is a critical step in promoting the orderly entry of Müller glia into a regenerative program. However, the molecular switch governing this divergent fate decision remains elusive. Here, through RNA-seq and scRNA-seq, we confirm the upstream determinant of Müller glia fate after retinal injury.
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