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CUT&Tag profiling of JUND chromatin binding in human mast cell line LAD2 under SCF stimulation and imatinib perturbation

GSE316333 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2026/01/14 Platform GPL24676
Summary
Mast cells respond to cytokine cues through rapid transcriptional rewiring. Here we generated CUT&Tag profiles of the transcription factor JUND in the human mast cell line LAD2 under three culture conditions: SCF withdrawal (EM), SCF supplementation (SCF), and SCF withdrawal plus imatinib treatment (IM). Two biological replicates were collected for each condition. Libraries were sequenced as paired-end reads and processed by adapter/quality filtering, alignment to the human reference genome (GRCh38/hg38), peak calling, and generation of normalized genome browser tracks. This dataset provides a resource to examine how SCF signaling and c-KIT pathway inhibition reshape JUND occupancy in mast cells.
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Direct links to NCBI, no account and no request form: the whole study as GSE316333_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1402331 and SRA study SRP661863. Searching any of these in the dataset finder brings you back here.

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