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RNA-seq analysis of MDA-MB-231 triple-negative breast cancer cells treated with CIr2 for 24 h

GSE316771 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/21 Platform GPL16791
Summary
This study investigates the transcriptomic alterations induced by a novel cyclometalated iridium(III) compound, CIr2, in triple-negative breast cancer (TNBC) cells. MDA-MB-231 cells were treated with CIr2 for 24 h, followed by RNA sequencing to profile global gene expression changes. The RNA-seq data were integrated with functional assays and morphological analyses to explore cellular responses associated with mitochondrial dysfunction, reactive oxygen species production, endoplasmic reticulum stress, and MAPK signaling. This dataset provides a resource for examining CIr2-induced transcriptional programs related to non-apoptotic cell death pathways in TNBC cells.
Published in
A cyclometalated iridium(III) complex induces paraptotic cell death via mitochondrial dysfunction and ER stress in triple-negative breast cancer cells
Lin H, Wei J, Yao W et al. · Frontiers in pharmacology 2026 · PMID 41669679 · doi:10.3389/fphar.2026.1739226
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Direct links to NCBI, no account and no request form: the whole study as GSE316771_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1404173 and SRA study SRP663618. Searching any of these in the dataset finder brings you back here.

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