TERT drives liver tumorigenesis and immune reprogramming independently of telomere elongation
RNA-seq (gene expression) · mouse · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 13 distinct titles, 1 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- TERT drives liver tumorigenesis beyond telomere elongationLife science alliance · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE317255_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1406632 and SRA study SRP665555. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 15 sample titles: 13 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9468061 p_961
- GSM9468062 p_663
- GSM9468063 p_941
- GSM9468064 NT_992
- GSM9468065 L981_CI
- GSM9468066 L984_CI
- GSM9468067 p_662_T
- GSM9468068 p_663_T
- GSM9468069 p_941_T
- GSM9468070 T_992
- GSM9468071 L981T_CI
- GSM9468072 L984T_CI
- GSM9468073 LT20_1_Tci
- GSM9468074 LT20_3_Tci
- GSM9468075 LT24_Tci
- GSE247845 FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma [RNA-Seq] 20 samples shares reprogramming, drives
- GSE295472 NOD2 drives regenerative fetal-like reprogramming in the intestinal epithelium 15 samples shares reprogramming, drives
- GSE302786 Metabolic reprogramming drives pancreatic β cell neogenesis from α cells [RNA-Seq] 9 samples shares reprogramming, drives
- GSE237954 Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer 122 samples shares reprogramming, drives
- GSE301501 Extracellular matrix reprogramming by the YAP/TAZ/TGF-ß2 axis drives immune exclusion in cholangiocarcinoma models 45 samples shares reprogramming, drives
- GSE315303 Pygo2 Loss Induces Tertiary Lymphoid Structure Formation and Enhances Immunotherapy and Castration Responses in Prostate Cancer 22 samples shares tert
- GSE241725 Evolutionarily conserved role of Telomerase reverse transcriptase (TERT) in programming the microenvironment via regulation of cGAS/STING pathway 15 samples shares tert
- GSE302373 Nociceptive innervation limits tertiary lymphoid structures to promote lung cancer 10 samples shares tert
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.