GEO series
scRNA-seq of bone marrow and splenic emergency granulopoiesis
GSE317310
Mus musculus
Expression profiling by high throughput sequencing; Other
20 samples
2026/04/17
GPL24247
Summary
We performed scRNA-seq analysis using the 10X genomics platform of mice following a model of extramedullary hematopoiesis or control. Here, we isolated bone marrow, spleen and blood Gr1+and cKit+-enriched cells to investigate the dynamics of production across both sites of origin. In addition, we performed the following treatments and blood cells were sorted following similar strategy: (1) Splenectomy: a group of mice was subjected to splenectomy before CPM/AMD treatment; (2) partial irradiation with a shield protecting the abdominal region of the mouse followed by CPM/AMD treatment; (3) Mice treated with CPM/AMD were administered with anti-CXCR2 depleting antibody.
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Paper (PMID 41996475) ↗
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