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RNA-seq of human NK cells that were co-cultured with DU-145 cells, which were pre-treated with hIgG1 isotype, 7C6-hIgG1, or 7C6-GAALIE

GSE317314 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/05 Platform GPL24676
Summary
7C6 is a monoclonal antibody that inhibits the shedding of MICA and MICB, which are stress-induced ligands often expressed by tumor cells. We developed a new version of 7C6, 7C6-GAALIE, which better binds Fc gamma-activating receptors, and analyzed how it reprograms human NK cell gene expression in vitro after co-culture with a target cell line, DU-145.
Published in
A MICA/B GAALIE-mutant antibody elicits potent natural killer cell-driven immunity in solid and hematologic malignancy models
Pimenta R, Maurer S, Zhong X et al. · Cell reports. Medicine 2026 · PMID 41999749 · doi:10.1016/j.xcrm.2026.102753
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Also filed as BioProject PRJNA1406726 and SRA study SRP665632. Searching any of these in the dataset finder brings you back here.

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