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RUVBL2 transcriptionally regulates the mitophagy pathway in gallbladder cancer cells

GSE317548 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2026/01/30 Platform GPL24676
Summary
Gemcitabine resistance in gallbladder cancer poses a significant challenge to patient prognosis. This study identified RUVBL2 as a critical factor contributing to gemcitabine resistance in gallbladder cancer. Further analysis, combining ChIP-seq and gene enrichment studies, revealed that RUVBL2 regulates the mitophagy pathway. This regulation helps maintain intracellular redox homeostasis in gallbladder cancer cells following gemcitabine treatment.
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Also filed as BioProject PRJNA1414444 and SRA study SRP666419. Searching any of these in the dataset finder brings you back here.

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