Lung gene expression in WT and estrogen receptor alpha and beta knockout mice exposed to house dust mites
RNA-seq (gene expression) · mouse · 72 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 72 samples: 12 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Estrogen receptor β regulates sex-dependent airway mechanics and inflammation in a murine model of allergen exposurePhysiological reports · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE317602_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1414532 and SRA study SRP666487. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 71 samples.
How we read this: 12 replicated groups read from 72 sample titles; they account for 71 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9474907 F, Esr1KO, HDM, Rep 1 F, Esr1KO, HDM,
- GSM9474908 F, Esr1KO, PBS, Rep 1 F, Esr1KO, PBS,
- GSM9474909 M, Esr1KO, HDM, Rep 1 M, Esr1KO, HDM,
- GSM9474910 M, Esr1KO, PBS, Rep 1 M, Esr1KO, PBS,
- GSM9474911 M, WT, PBS, Rep 1 M, WT, PBS,
- GSM9474912 M, WT, PBS, Rep 2 M, WT, PBS,
- GSM9474913 M, WT, PBS, Rep 3 M, WT, PBS,
- GSM9474914 M, WT, PBS, Rep 4 M, WT, PBS,
- GSM9474915 M, WT, HDM, Rep 1 M, WT, HDM,
- GSM9474916 M, WT, HDM, Rep 2 M, WT, HDM,
- GSM9474917 M, WT, HDM, Rep 3 M, WT, HDM,
- GSM9474918 F, Esr2KO, HDM, Rep 1 F, Esr2KO, HDM,
- GSM9474919 M, Esr2KO, PBS, Rep 1 M, Esr2KO, PBS,
- GSM9474920 M, Esr2KO, PBS, Rep 2 M, Esr2KO, PBS,
- GSM9474921 F, Esr2KO, PBS, Rep 1 F, Esr2KO, PBS,
- GSM9474922 M, Esr2KO, HDM, Rep 1 M, Esr2KO, HDM,
- GSM9474923 M, Esr2KO, HDM, Rep 2 M, Esr2KO, HDM,
- GSM9474924 M, Esr2KO, HDM, Rep 3 M, Esr2KO, HDM,
- GSM9474925 F, WT, PBS, Rep 1 F, WT, PBS,
- GSM9474926 F, WT, PBS, Rep 2 F, WT, PBS,
- GSM9474927 F, WT, PBS, Rep 3 F, WT, PBS,
- GSM9474928 F, WT, PBS, Rep 4 F, WT, PBS,
- GSM9474929 F, WT, HDM, Rep 1 F, WT, HDM,
- GSM9474930 F, WT, HDM, Rep 2 F, WT, HDM,
- GSM9474931 F, WT, HDM, Rep 3 F, WT, HDM,
- GSM9474932 F, Esr2KO, HDM, Rep 2 F, Esr2KO, HDM,
- GSM9474933 F, Esr2KO, PBS, Rep 2 F, Esr2KO, PBS,
- GSM9474934 F, Esr2KO, PBS, Rep 3 F, Esr2KO, PBS,
- GSM9474935 F, Esr2KO, HDM, Rep 3 F, Esr2KO, HDM,
- GSM9474936 F, Esr2KO, PBS, Rep 4 F, Esr2KO, PBS,
- GSM9474937 F, Esr2KO, PBS, Rep 5 F, Esr2KO, PBS,
- GSM9474938 F, Esr2KO, HDM, Rep 4 F, Esr2KO, HDM,
- GSM9474939 F, Esr2KO, PBS, Rep 6 F, Esr2KO, PBS,
- GSM9474940 M,Esr2KO, PBS, Rep 3
- GSM9474941 M, Esr2KO, PBS, Rep 4 M, Esr2KO, PBS,
- GSM9474942 F, Esr2KO, HDM, Rep 5 F, Esr2KO, HDM,
- GSM9474943 F, Esr2KO, PBS, Rep 7 F, Esr2KO, PBS,
- GSM9474944 F, Esr1KO, HDM, Rep 3 F, Esr1KO, HDM,
- GSM9474945 M, Esr2KO, PBS, Rep 5 M, Esr2KO, PBS,
- GSM9474946 F, WT, HDM, Rep 4 F, WT, HDM,
+ 32 more — browse all 72 samples with per-sample file links →
- GSE268029 Transcriptomic profiling of the oocyte-cumulus-granulosa cell complex from estrogen receptor beta knockout mice 93 samples shares estrogen, receptor, knockout
- GSE314584 Toll-Like-Receptor 5 Reduces Lung Dysbiosis and Protects Against Pulmonary Fibrosis 124 samples shares receptor, lung
- GSE313359 Hippocampal estrogen levels, receptor types and epigenetics contribute to sex-specific memory-vulnerabilities to concurrent acute stresses [Cut & Run] 45 samples shares estrogen, receptor
- GSE306035 scRNA-Seq of immune populations from nasal mucosa and lungs of C57BL/6 mice and BLT1 receptor deficient mice infected intranasally with MCMV K181 strain 20 samples shares receptor, lung
- GSE217662 Decoding Trp53 regulatory program with knockout cell transcriptomic landscape analyses [scRNA-seq] 247 samples shares knockout
- GSE292884 RNA Sequencing of Liver Samples from UM-HET3 Mice Exposed to Various Compounds from the ITP Study 182 samples shares exposed
- GSE229815 Transcriptional profiling of 12 month striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Msh2 heterozygous or homozygous conditional knockout mice [Msh2_12mon] 138 samples shares knockout
- GSE307181 Sex specific correction of maternal inflammation-induced behavioral abnormalities by the inhibition of colony-stimulating factor 1 receptor 96 samples shares receptor
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.