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Identification progenitor Keratinocyte Subpopulations in HaCaT via high throughput sequencing

GSE317695 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2026/01/31 Platform GPL34284
Summary
Epidermal progenitor cells rely on tightly regulated transcriptional and epigenetic programs to preserve cellular plasticity and prevent premature differentiation; however, these regulatory mechanisms remain incompletely characterized. In this study, we investigated the transcriptomic architecture of progenitor keratinocyte subpopulations isolated from HaCaT cells using fluorescence-activated cell sorting and bulk RNA sequencing. Differential expression analysis revealed distinct protein-coding and long non-coding RNA (lncRNA) profiles between subpopulations enriched for progenitor-associated markers and more differentiated cells. Enrichment analyses providing a transcriptomic framework for exploring epigenetic regulation of keratinocyte progenitor identity.
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Also filed as BioProject PRJNA1414665 and SRA study SRP666917. Searching any of these in the dataset finder brings you back here.

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