← BioTransfer GEO Dataset Finder
GEO series

The Role and Therapeutic Potential of Splicing Factor SF3B6 in Hepatocellular Carcinoma

GSE318429 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/11 Platform GPL29480
Summary
Hepatocellular carcinoma (HCC) is a major global health burden, and effective systemic therapies remain limited. Dysregulated RNA splicing, driven by aberrant activity of core spliceosome components, has emerged as a key hallmark of cancer. SF3B6, a structural subunit of the SF3B complex within the U2 small nuclear ribonucleoprotein (snRNP), is required for branch-point recognition during spliceosome assembly, but its mechanistic role in HCC is poorly understood. Pan-cancer bioinformatic analyses further highlight spliceosome components as recurrently altered, essential for tumor cell survival, and associated with poor prognosis, suggesting that spliceosome subunits may represent shared oncogenic vulnerabilities.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE318429_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1418718 and SRA study SRP674631. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.