Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cortical organoids [RNA-Seq]
RNA-seq (gene expression) · human · 8 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 8 samples: 2 × Cortical organoids. isogenic control for MECP2[V247X], vs 2 × Cortical organoids. MECP2[V247X] mutation, vs 2 × Cortical organoids. isogenic control for MECP2[R306C], vs 2 × Cortical organoids. MECP2[R306C] mutation,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cortical organoidsNature communications · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE318601_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1419288 and SRA study SRP674998. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 4 replicated groups read from 8 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9498150 Cortical organoids. isogenic control for MECP2[V247X], rep1 Cortical organoids. iso…
- GSM9498151 Cortical organoids. isogenic control for MECP2[V247X], rep2 Cortical organoids. iso…
- GSM9498152 Cortical organoids. MECP2[V247X] mutation, rep1 Cortical organoids. MEC…
- GSM9498153 Cortical organoids. MECP2[V247X] mutation, rep2 Cortical organoids. MEC…
- GSM9498154 Cortical organoids. isogenic control for MECP2[R306C], rep1 Cortical organoids. iso…
- GSM9498155 Cortical organoids. isogenic control for MECP2[R306C], rep2 Cortical organoids. iso…
- GSM9498156 Cortical organoids. MECP2[R306C] mutation, rep1 Cortical organoids. MEC…
- GSM9498157 Cortical organoids. MECP2[R306C] mutation, rep2 Cortical organoids. MEC…
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.