← BioTransfer GEO Dataset Finder
GEO series

Transcriptomic profiling of AC16 cardiomyocytes under TPEN-induced zinc deficiency

GSE318912 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/30 Platform GPL23227
Summary
Zinc deficiency is an important risk factor for myocardial injury, yet the underlying cytoprotective mechanisms remain incompletely understood. In this study, bulk RNA sequencing was performed in human AC16 cardiomyocytes treated with the zinc chelator TPEN or vehicle control to characterize transcriptional changes induced by zinc deficiency. Differential expression and pathway enrichment analyses revealed activation of apoptosis- and stress-related pathways, providing a transcriptomic framework for subsequent mechanistic investigations of ATF3-mediated mitochondrial and survival signaling.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE318912_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1420801 and SRA study SRP675818. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.