Macrophage EHD1 promotes inflammation and stabilizes sortilin to accelerate atherosclerosis
RNA-seq (gene expression) · mouse · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 3 × M0-siCON vs 3 × M0-siEHD1 vs 3 × M1-siCON vs 3 × M1-siEHD1Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Macrophage EHD1 Promotes Inflammation and Stabilizes Sortilin to Accelerate AtherosclerosisCirculation research · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE319030_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1421976 and SRA study SRP676098. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 14 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9508230 M0-siCON-1 M0-siCON
- GSM9508231 M0-siCON-2 M0-siCON
- GSM9508232 M0-siCON-3 M0-siCON
- GSM9508233 M0-siEHD1-1 M0-siEHD1
- GSM9508234 M0-siEHD1-2 M0-siEHD1
- GSM9508235 M0-siEHD1-3 M0-siEHD1
- GSM9508236 M1-siCON-1 M1-siCON
- GSM9508237 M1-siCON-2 M1-siCON
- GSM9508238 M1-siCON-3 M1-siCON
- GSM9508239 M1-siEHD1-1 M1-siEHD1
- GSM9508240 M1-siEHD1-2 M1-siEHD1
- GSM9508241 M1-siEHD1-3 M1-siEHD1
- GSM9508274 WT scRNA
- GSM9508275 Ehd1-KO scRNA
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- GSE279117 HIF1α deletion promotes mitochondrial repurposing in bone marrow-derived macrophages, but not in tissue-resident alveolar macrophages 24 samples shares macrophage, promotes
- GSE300299 Chikungunya virus persists in joint-associated macrophages and promotes chronic disease in mice [scRNA-seq] 12 samples shares macrophage, promotes
- GSE250551 Targeting inflammation with chimeric antigen receptor macrophages using a signal switch 32 samples shares macrophage
- GSE303772 Ontogenically distinct alveolar macrophages mediate cigarette smoke-induced inflammation and damage [RNA-Seq] 24 samples shares macrophage
- GSE210798 Splenic CD169+Tim4+ Marginal Zone Metallophilic Macrophages Are Essential for Wound Healing and Resolution of Inflammation After Myocardial Infarction 24 samples shares macrophage
- GSE282695 STAT3 regulates pathogen control and clearance in macrophages by reprogramming inflammation-induced microbial defense response 18 samples shares macrophage
- GSE309415 Bile acid receptor Tgr5 prevents macrophage hyperinflammation during bacterial sepsis through metabolic and epigenetic silencing 12 samples shares macrophage
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.