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The APC/C subunit APC7 promotes hepatocellular carcinoma progression by mediating ubiquitination and degradation of LATS1/2 to activate YAP/TAZ

GSE319107 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/15 Platform GPL24676
Summary
Introduction: The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase critically involved in cell cycle regulation. However, the pathological functions of its individual subunits, particularly in hepatocellular carcinoma (HCC), remain largely unexplored. Objectives: To systematically analyze the expression and prognosis of APC/C in pan-cancer, and also focus on studying the function and mechanism of APC7 in the progression of HCC.
Published in
The APC/C subunit APC7 promotes hepatocellular carcinoma progression by mediating ubiquitination and degradation of LATS1 to activate YAP/TAZ
Sun Y, Zhang R, Guo Y et al. · Biology direct 2026 · PMID 41866505 · doi:10.1186/s13062-026-00759-7
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Also filed as BioProject PRJNA1422104 and SRA study SRP676265. Searching any of these in the dataset finder brings you back here.

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