GEO series
Homo sapiens bulk RNA-seq for iMGLs and iMGL-motor neuron co-cultures with cGAS inhibitor
GSE319347
Homo sapiens
Expression profiling by high throughput sequencing
18 samples
2026/02/16
GPL24676
Summary
This study investigates the role of cGAS signaling in amyotrophic lateral sclerosis using human microglial-like cells (iMGLs) and iMGL-motor neuron co-cultures. Bulk RNA sequencing was performed to assess transcriptional and RNA splicing changes associated with TDP-43 pathology and their modulation by pharmacological cGAS inhibition.
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