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ChIP-seq analysis of HT-29 cells treated with the KDM5B inhibitors JB-157 or JB-161

GSE319663 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 3 samples Submitted 2026/07/01 Platform GPL34284
Summary
KDM5B, a member of the KDM5 family of histone demethylases, functions as a key epigenetic regulator by removing di- and trimethyl groups from H3K4 (H3K4me2/3), thereby promoting transcriptional repression. It is involved in fundamental biological processes, including development, stem cell maintenance, and tumorigenesis, and its dysregulation has been associated with multiple cancer types. Given its critical role in cancer biology, KDM5B has emerged as an attractive target for therapeutic intervention. Therefore, we conducted a screening campaign to identify novel KDM5B inhibitors. In this study, we investigated whether the KDM5B inhibitors JB-157 and JB-161, identified through our screening, induce chromatin remodeling in HT-29 cells.
Published in
Identification of Novel Small-Molecule Inhibitors Targeting KDM5B and Evaluation of Their Antitumour Effects
Hara T, Meng S, Konno M et al. · Cancer medicine 2026 · PMID 42324589 · doi:10.1002/cam4.72058
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Also filed as BioProject PRJNA1424928 and SRA study SRP677688. Searching any of these in the dataset finder brings you back here.

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