GEO series
Single-cell transcriptomics reveals etiology-specific T-cell heterogeneity in hepatocellular carcinoma and implicates regulatory
GSE319709
Homo sapiens
Expression profiling by high throughput sequencing
18 samples
2026/02/20
GPL24676
Summary
Hepatocellular carcinoma (HCC) exhibits remarkable etiological heterogeneity, with hepatitis B virus (HBV) infection and metabolic dysfunction-associated steatohepatitis (MASH) emerging as two leading causes. The tumor microenvironment (TME), particularly T cell subsets, plays a pivotal role in tumor progression and immunotherapy response. However, the etiology-specific T cell landscapes in HBV-HCC and MASH-HCC remain poorly characterized.
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