Bulk RNA-sequencing of soft tissue sarcomas from patients undergoing neoadjuvant BO-112 and hypofractionated radiation therapy with or without nivolumab in soft tissue sarcoma
RNA-seq (gene expression) · human · 41 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Soft tissue sarcomaThis series is part of our curated briefing on it.
- Samples
- 41 samples: 14 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Neoadjuvant BO-112 and Hypofractionated Radiation Therapy with or without Nivolumab in Soft-Tissue Sarcoma: Preclinical and Phase I ResultsCancer discovery · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE319794_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1425103 and SRA study SRP677874. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 41 samples.
How we read this: 14 replicated groups read from 41 sample titles; they account for 41 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9526452 B0_112_001_T1 B0_112_001_T
- GSM9526453 B0_112_001_T2 B0_112_001_T
- GSM9526454 B0_112_001_T3 B0_112_001_T
- GSM9526455 B0_112_002_T1 B0_112_002_T
- GSM9526456 B0_112_002_T2 B0_112_002_T
- GSM9526457 B0_112_002_T3 B0_112_002_T
- GSM9526458 B0_112_002_T4 B0_112_002_T
- GSM9526459 B0_112_003_T1 B0_112_003_T
- GSM9526460 B0_112_003_T3 B0_112_003_T
- GSM9526461 B0_112_003_T4 B0_112_003_T
- GSM9526462 B0_112_004_T1 B0_112_004_T
- GSM9526463 B0_112_004_T2 B0_112_004_T
- GSM9526464 B0_112_004_T3 B0_112_004_T
- GSM9526465 B0_112_007_T1 B0_112_007_T
- GSM9526466 B0_112_007_T2 B0_112_007_T
- GSM9526467 B0_112_007_T4 B0_112_007_T
- GSM9526468 B0_112_009_T1 B0_112_009_T
- GSM9526469 B0_112_009_T2 B0_112_009_T
- GSM9526470 B0_112_009_T4 B0_112_009_T
- GSM9526471 B0_112_010_T1 B0_112_010_T
- GSM9526472 B0_112_010_T2 B0_112_010_T
- GSM9526473 B0_112_010_T3 B0_112_010_T
- GSM9526474 B0_112_011_T1 B0_112_011_T
- GSM9526475 B0_112_011_T2 B0_112_011_T
- GSM9526476 B0_112_011_T4 B0_112_011_T
- GSM9526477 B0_112_012_T1 B0_112_012_T
- GSM9526478 B0_112_012_T4 B0_112_012_T
- GSM9526479 B0_112_013_T1 B0_112_013_T
- GSM9526480 B0_112_013_T2 B0_112_013_T
- GSM9526481 B0_112_013_T3 B0_112_013_T
- GSM9526482 B0_112_013_T4 B0_112_013_T
- GSM9526483 B0_112_014_T1 B0_112_014_T
- GSM9526484 B0_112_014_T2 B0_112_014_T
- GSM9526485 B0_112_014_T4 B0_112_014_T
- GSM9526486 B0_112_015_T1 B0_112_015_T
- GSM9526487 B0_112_015_T4 B0_112_015_T
- GSM9526488 B0_112_016_T1 B0_112_016_T
- GSM9526489 B0_112_016_T2 B0_112_016_T
- GSM9526490 B0_112_016_T4 B0_112_016_T
- GSM9526491 B0_112_017_T1 B0_112_017_T
+ 1 more — browse all 41 samples with per-sample file links →
- GSE240287 RNA-sequencing of matched samples from rhabdomyosarcoma samples, obtained before therapy and mid-treatment resection 18 samples same disease briefing · shares rna-sequencing
- GSE274640 MYOD1L122R induces cancer stem cell pathways to impart chemotherapy and radiation-resistance in aggressive rhabdomyosarcoma. 80 samples same disease briefing · shares radiation
- GSE312030 Combined inhibition of HRAS and MEK induces tumor regression and restores myogenic differentiation in HRAS-mutant rhabdomyosarcoma 159 samples same disease briefing
- GSE273829 GABA promotes resistance to immunotherapy of patients with TLS-positive tumors [RNA-seq] 92 samples same disease briefing
- GSE300974 CDK8 Inhibition Releases the Muscle Differentiation Blockade in Fusion-driven Alveolar Rhabdomyosarcoma [RNA-seq] 30 samples same disease briefing
- GSE314949 RNA Seq of rhabdomyosarcoma cells with sgRNA targeting oncofusion interacting proteins 30 samples same disease briefing
- GSE279954 mRNA/sRNA Co-Sequencing Reveals Multiple New Targeted Therapy Candidates in Rhabdomyosarcoma 26 samples same disease briefing
- GSE292872 FANCM is Required for the PAX3::FOXO1-Driven Oncogenic Program in Rhabdomyosarcoma [RNA-Seq] 21 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.