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Transcriptional regulation by TES and TEAD1 in SNB19 glioblastoma cells: RNA-seq

GSE319888 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/23 Platform GPL21290
Summary
This study investigates transcriptional regulation by TES (TEAD1 Epigenetic Silencer, an engineered epigenetic silencer factor targeting the YAP/TAZ-TEAD axis) in SNB19 glioblastoma cells using RNA-seq. TES was engineered by fusing the KRAB domain, the catalytic domain of DNMT3A together with DNMT3L, and the N-terminal 166 amino acids of TEAD1. RNA-seq was performed 48 hours after lentiviral transduction to identify differentially expressed genes upon TES expression compared to GFP control in three biological replicates per condition. TES expression induced widespread transcriptional repression of YAP/TAZ-dependent gene programs, with downregulated genes enriched for cell-cycle regulation and TEAD family transcription factor binding sites.
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Direct links to NCBI, no account and no request form: the whole study as GSE319888_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1425482 and SRA study SRP678024. Searching any of these in the dataset finder brings you back here.

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