← BioTransfer GEO Dataset Finder
GEO series

FOXM1 is prevalent in lung cancer and targetable via T cell receptor engineering

GSE319956 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/11 Platform GPL24676
Summary
We identified epitopes derived from FOXM1 which were immunogenic on HLA-A*02:01, HLA-A*24:02, and HLA-A*23:01, endogenously-processed and presented, and resulted in T cell activation and cytotoxic T cell responses. Following the generation of TCR-T cells, sensitivity and specificity were confirmed by peptide dose-response and X-scan, respectively. Most importantly, adoptive transfer of TCR engineered T cells led to a significant reduction in tumor growth, as well as significantly prolonged survival in NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) tumor-bearing murine model. Our studies confirm the immunogenicity of FOXM1 and feasibility of targeting this antigen using TCR-engineering.
Published in
FOXM1-Specific TCR-Engineered T Cells Target Non-Small Cell Lung Cancer
Bontekoe E, Zhang M, Jiang P et al. · Cancer immunology research 2026 · PMID 41854516 · doi:10.1158/2326-6066.CIR-25-0605
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE319956_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1425783 and SRA study SRP678165. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.