GEO series
Gene expression profiles of NSCLC cells treated with almonertinib, paclitaxel, and their combination
GSE320166
Homo sapiens
Expression profiling by high throughput sequencing
24 samples
2026/02/26
GPL34284
Summary
Transcriptomic profiling revealed that the combination therapy elicits an unique molecular signature distinct from either monotherapy alone. We identified a specific gene cluster (C8) that was suppressed only by the drug combination, and mainly enriched in cell cycle, DNA replication and mitochondrial function in PC9 cells. The downregulation of these processes was validated in H1975 cells, and key genes (e.g., XRCC2, SKA3, TOMM40) also exhibited prognostic relevance.
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