GEO series
Characterization of TLR signaling in Ticam2-/- macrophages
GSE321707
Mus musculus
Expression profiling by high throughput sequencing
30 samples
2026/08/07
GPL24247
Summary
Early Toll-like receptor (TLR) signaling termination in TRAM (Ticam2) KO macrophages selectively impairs activation of secondary response genes (SRG) and interferon-stimulated genes (ISGs), whereas primary response gene (PRG) induction remains largely intact. We performed bulk RNA-Seq on LTA- or LPS-stimulated primary WT and Ticam2-/- BMDMs after 2 h and 6 h of PAMP-treatment to analyze this phenomenom.
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