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A Positive Feedback Loop Between TKT and c-Myc Drives TACE Resistance In Hepatocellular Carcinoma

GSE322668 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/07 Platform GPL24676
Summary
Hepatocellular carcinoma (HCC) often receives transarterial chemoembolization (TACE), yet clinical benefit is limited by resistance driven by ischemia-induced adaptations. This study explains how transketolase (TKT) in the pentose phosphate pathway (PPP) modulates HCC progression and TACE refractoriness, and clarifies its mechanistic connection to oncogenic signaling.
Published in
A positive feedback loop between TKT and c-Myc drives TACE resistance in hepatocellular carcinoma
Xiao Y, Liu M, Zhou Y et al. · Cell death discovery 2026 · PMID 42014677 · doi:10.1038/s41420-026-03125-8
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Also filed as BioProject PRJNA1430878 and SRA study SRP680354. Searching any of these in the dataset finder brings you back here.

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